PLATE VI.
PLATE VI.
PLATE VI.
Fig. 1.—Two cells from a fresh nodule in 1 per cent. osmic acid (Gundlach, No. viii).Fig. 2.—Part of a section of a cutaneous leproma. Round cells with clear stellate cells between them (Hartnack, No. ix).Fig. 3.—From a corneal leproma. Round cells with corneal corpuscles between them (Hartnack, No. ix).Fig. 4.—From the border of a corneal leproma. Capillary surrounded by round cells. Müller’s Fluid (Hartnack, No. ix).Fig. 5.—From the inside of a corneal leproma. A capillary surrounded by round cells in among globi and corneal corpuscles unchanged or filled with brown granules. Müller’s Fluid (Hartnack, No. ix).Fig. 6.—The brushed-out network of a cutaneous leproma (Hartnack, No. ix).Fig. 7.—From a corneal leproma. Capillary surrounded by round cells free from bacilli, and outside these, cells filled with bacilli. Seibert homogen. immersion 1/16.Fig. 8.—Cells from a cutaneous leproma. Eosin, Bismarck brown, and Gentian-violet. Hardening in Fleming’s Solution. Seibert homogen. immersion 1/16.
Fig. 1.—Two cells from a fresh nodule in 1 per cent. osmic acid (Gundlach, No. viii).
Fig. 2.—Part of a section of a cutaneous leproma. Round cells with clear stellate cells between them (Hartnack, No. ix).
Fig. 3.—From a corneal leproma. Round cells with corneal corpuscles between them (Hartnack, No. ix).
Fig. 4.—From the border of a corneal leproma. Capillary surrounded by round cells. Müller’s Fluid (Hartnack, No. ix).
Fig. 5.—From the inside of a corneal leproma. A capillary surrounded by round cells in among globi and corneal corpuscles unchanged or filled with brown granules. Müller’s Fluid (Hartnack, No. ix).
Fig. 6.—The brushed-out network of a cutaneous leproma (Hartnack, No. ix).
Fig. 7.—From a corneal leproma. Capillary surrounded by round cells free from bacilli, and outside these, cells filled with bacilli. Seibert homogen. immersion 1/16.
Fig. 8.—Cells from a cutaneous leproma. Eosin, Bismarck brown, and Gentian-violet. Hardening in Fleming’s Solution. Seibert homogen. immersion 1/16.
Plate VI.Cells
Plate VI.
Plate VI.
PLATE VII.
PLATE VII.
Fig. 1.—Cells and globi from cutaneous lepromata. Müller’s Fluid (Hartnack, No. ix).Fig. 2.—Globi from a leprous spleen.Fig. 3.—Two globi from the retina.
Fig. 1.—Cells and globi from cutaneous lepromata. Müller’s Fluid (Hartnack, No. ix).
Fig. 2.—Globi from a leprous spleen.
Fig. 3.—Two globi from the retina.
Plate VII.Cells
Plate VII.
Plate VII.
PLATE VIII.
PLATE VIII.
Fig. 1.—Corneal corpuscles filled with brown granules (Hartnack, No. ix).Fig. 2.—From a leproma of the iris. Round cells with stellate cells (Hartnack, No. ix).Fig. 3.—Corneal space with round cells near the corneal corpuscles (Hartnack, No. ix).Fig. 4.—Cells with two nuclei full of bacilli from a cutaneous leproma. Seibert homog. immersion 1/16.Fig. 5.—Two cells with bacilli from a leprous spleen. Fuchsin, methyl blue. Seibert homog. immersion 1/16.Fig. 6.—From a leprous liver. White blood corpuscles with bacilli in a capillary. Seibert homog. immersion 1/16.
Fig. 1.—Corneal corpuscles filled with brown granules (Hartnack, No. ix).
Fig. 2.—From a leproma of the iris. Round cells with stellate cells (Hartnack, No. ix).
Fig. 3.—Corneal space with round cells near the corneal corpuscles (Hartnack, No. ix).
Fig. 4.—Cells with two nuclei full of bacilli from a cutaneous leproma. Seibert homog. immersion 1/16.
Fig. 5.—Two cells with bacilli from a leprous spleen. Fuchsin, methyl blue. Seibert homog. immersion 1/16.
Fig. 6.—From a leprous liver. White blood corpuscles with bacilli in a capillary. Seibert homog. immersion 1/16.
Plate VIII.Cells
Plate VIII.
Plate VIII.
PLATE IX.
PLATE IX.
Fig. 1.—From a leprous liver. Bacilli in an endothelial cell of a capillary. Seibert homog. immersion 1/16.Fig. 2.—Piece of a very leprous liver. Capsule below, cut surface above.Fig. 3.—Cut surface of a very leprous spleen.Figs.4 and5andPlate X,Fig. 1.—Cross section of the seminal canals with bacilli around the nuclei of the walls and in the epithelium; inPlate X,Fig. 1, is shown an epithelial cell filled with bacilli.
Fig. 1.—From a leprous liver. Bacilli in an endothelial cell of a capillary. Seibert homog. immersion 1/16.
Fig. 2.—Piece of a very leprous liver. Capsule below, cut surface above.
Fig. 3.—Cut surface of a very leprous spleen.
Figs.4 and5andPlate X,Fig. 1.—Cross section of the seminal canals with bacilli around the nuclei of the walls and in the epithelium; inPlate X,Fig. 1, is shown an epithelial cell filled with bacilli.
Plate IX.Cells
Plate IX.
Plate IX.
PLATE X.
PLATE X.
Fig. 1.—Epithelial cell from a seminal canal, filled with bacilli.Fig. 2.—A globus with a vacuole in which are fragments stained with Bismarck brown, probably the remains of nuclei.Fig. 3.—A globus lying in a cell; the nucleus and a part of the cell-protoplasm preserved.Fig. 4.—An epithelial cell from a seminal canal, filled with bacilli broken down into granules.Fig. 5.—Cross section of a blood-vessel with bacilli in the endothelium and a white blood corpuscle filled with bacilli.Fig. 6.—Longitudinal section of a blood-vessel showing bacilli in the endothelium, and a fibrinous coagulum enclosing two white blood corpuscles, one of them filled with bacilli.Fig. 7.—Bacilli free between the red blood corpuscles.Fig. 8.—A connective tissue space from the tunica albuginea filled with bacilli.Fig. 9.—Cross section of a blood-vessel with bacilli around the nuclei of the surrounding connective tissue.All the preparations from the testicle were hardened in Fleming’s or Müller’s solutions, and the drawings made with a Seibert homog. immersion lens 1/16.Plate IX,Fig. 5with Seibert 1/8.
Fig. 1.—Epithelial cell from a seminal canal, filled with bacilli.
Fig. 2.—A globus with a vacuole in which are fragments stained with Bismarck brown, probably the remains of nuclei.
Fig. 3.—A globus lying in a cell; the nucleus and a part of the cell-protoplasm preserved.
Fig. 4.—An epithelial cell from a seminal canal, filled with bacilli broken down into granules.
Fig. 5.—Cross section of a blood-vessel with bacilli in the endothelium and a white blood corpuscle filled with bacilli.
Fig. 6.—Longitudinal section of a blood-vessel showing bacilli in the endothelium, and a fibrinous coagulum enclosing two white blood corpuscles, one of them filled with bacilli.
Fig. 7.—Bacilli free between the red blood corpuscles.
Fig. 8.—A connective tissue space from the tunica albuginea filled with bacilli.
Fig. 9.—Cross section of a blood-vessel with bacilli around the nuclei of the surrounding connective tissue.
All the preparations from the testicle were hardened in Fleming’s or Müller’s solutions, and the drawings made with a Seibert homog. immersion lens 1/16.Plate IX,Fig. 5with Seibert 1/8.
Plate X.Cells
Plate X.
Plate X.
PLATE XI.
PLATE XI.
Fig. 1.—Bundle of nerve fibres from a ciliary nerve, the cells of Schwann’s sheath filled with brown granules.Fig. 2.—The myelin sheath pressed in by a cell filled with granules.Fig. 3.—Section from an old leprous macule.Fig. 4.—Section from a recent leprous macule.Both sections stained with Fuchsin and Methyl-green. Seibert homogen. immersion 1/16.
Fig. 1.—Bundle of nerve fibres from a ciliary nerve, the cells of Schwann’s sheath filled with brown granules.
Fig. 2.—The myelin sheath pressed in by a cell filled with granules.
Fig. 3.—Section from an old leprous macule.
Fig. 4.—Section from a recent leprous macule.
Both sections stained with Fuchsin and Methyl-green. Seibert homogen. immersion 1/16.
Plate XI.Cells
Plate XI.
Plate XI.
PLATE XII.
PLATE XII.
Fig. 1.—Cross section of a leprous ulnar nerve. The darkly hatched cells represent those filled with brown granules. It will be noted that the axial cylinder is wanting in many of the nerve fibres (Hartnack, No. ix).Fig. 2.—A piece of neurilemma with flat connective tissue cells lying on it, containing brown granules darkened by osmic acid (Gundlach, No. viii).
Fig. 1.—Cross section of a leprous ulnar nerve. The darkly hatched cells represent those filled with brown granules. It will be noted that the axial cylinder is wanting in many of the nerve fibres (Hartnack, No. ix).
Fig. 2.—A piece of neurilemma with flat connective tissue cells lying on it, containing brown granules darkened by osmic acid (Gundlach, No. viii).
Plate XII.Cells
Plate XII.
Plate XII.
PLATE XIII.
PLATE XIII.
Fig. 1.—Cross section of an atrophic muscle, growth of nuclei in the perimysium. Low power.Fig. 2.—Cross section of an atrophic muscle with great development of connective tissue. Low power.Fig. 3.—Proliferation of the nuclei of the perimysium. High power.
Fig. 1.—Cross section of an atrophic muscle, growth of nuclei in the perimysium. Low power.
Fig. 2.—Cross section of an atrophic muscle with great development of connective tissue. Low power.
Fig. 3.—Proliferation of the nuclei of the perimysium. High power.
Plate XIII.Cells
Plate XIII.
Plate XIII.
[1]See Neisser: Lepra in Ziemssen’s Handbook.
[1]See Neisser: Lepra in Ziemssen’s Handbook.
[2]Unna, zur Histologie der Leprösenhaut; in Leprastudien, Monatshefte für practische Dermatologie, Ergänzhungsheft, 1885.
[2]Unna, zur Histologie der Leprösenhaut; in Leprastudien, Monatshefte für practische Dermatologie, Ergänzhungsheft, 1885.
[3]In a nodule, with exudation, which we have recently examined, we have found bacilli in the epithelium, and there are in several places distinct leucocytic nuclei in the bacillary groups, thus showing emigrated cells with bacilli in the epithelium.
[3]In a nodule, with exudation, which we have recently examined, we have found bacilli in the epithelium, and there are in several places distinct leucocytic nuclei in the bacillary groups, thus showing emigrated cells with bacilli in the epithelium.
[4]Just as the manuscript of this treatise was completed, a year and a half ago, we obtained at an autopsy a lung in which there was tuberculosis, but at the same time probably leprosy also. Most unfortunately the bronchial glands were not preserved for microscopical examination. Dr. Lie also permits me to state that he has found leprosy bacilli in two kidneys and in one lung. He had diagnosed tuberculosis of the lung, but at the autopsy he found only an indurating pneumonia, containing lepra bacilli, and no tuberculosis. In the kidneys, of the same case, he found lepra bacilli in the glomeruli, and in the interstices between the cortical tubules. He will describe the case more fully later. This is a mere preliminary note.
[4]Just as the manuscript of this treatise was completed, a year and a half ago, we obtained at an autopsy a lung in which there was tuberculosis, but at the same time probably leprosy also. Most unfortunately the bronchial glands were not preserved for microscopical examination. Dr. Lie also permits me to state that he has found leprosy bacilli in two kidneys and in one lung. He had diagnosed tuberculosis of the lung, but at the autopsy he found only an indurating pneumonia, containing lepra bacilli, and no tuberculosis. In the kidneys, of the same case, he found lepra bacilli in the glomeruli, and in the interstices between the cortical tubules. He will describe the case more fully later. This is a mere preliminary note.
[5]Virchow’s Archiv, Bd. C. III.
[5]Virchow’s Archiv, Bd. C. III.
[6]Archive de Physiologie, Bern. 1882.
[6]Archive de Physiologie, Bern. 1882.
[7]Zeitschrift, par D. C. Danielssen, Bergen, 1891.
[7]Zeitschrift, par D. C. Danielssen, Bergen, 1891.