We were not made all at once, nor do we go to pieces all at once, like the "one-hoss shay." This is largely because we are not all of the same age, clear through. Some parts of us are older than other parts. We have always felt a difficulty, not to say a delicacy, in determining the age of a given member of the human species—especially of the gentler sex. Now we know the reason of it. From the biologic point of view, we are not an individual, but a colony; not a monarchy, but a confederacy of organ-states, each with its millions of cell-citizens. It is not merely editors and crowned heads who have a biologic right to say "We." Therefore, obviously, any statement that we make as to our age can be only in the nature of an average struck between the ages of our heart, lungs, liver, stomach; and as these vary in ancientness by thousands of years, the average must be both vague and misleading. The only reason why there is a mystery about a woman's age is that she is so intensely human and natural. The only statement as to our age that the facts would strictly justify us in making must partake of the vagueness of Mr. A. Ward's famous confession that he was "between twenty-three summers."
As we individually climb our own family-tree, from the first, one-celled droplet of animal jelly up, none ofour organs is older than we are, but a number of them are younger. The appendix is one of these. Now, by some curious coincidence, explain it as we may, some of our oldest organs are youngest, in the sense of most vigorous, elastic, and resisting, while some of our youngest are oldest, in the sense of decrepit, feeble, and unstable. It is perhaps only natural that an organ like the stomach, for instance, which has a record of honorable service and active duty millions of years long, should be better poised, more reliable, and more resourceful than one which, like the lung or the appendix, has, as it were, a "character" of only about one-tenth of that length. However this may be, the curious fact confronts us that scattered about through the body are structures and fragments, the remains of organs which at one time in our ancestral career were, under the then existing circumstances, of utility and value, but have now become mere survivals, remnants,—in the language of the day, "back numbers." Some of these have still a certain degree of utility, though diminished and still diminishing in size and functional importance, like our third molars or "wisdom" teeth, our fifth or "little" toes, our gall-bladder, our coccyx or tail-bone, the hair-glands scattered all over the now practically hairless surface of our bodies, and our once movable ears, which can no longer be "pricked," or laid back. These, though of far less utility and importance than they obviously were at one time, still earn their salt, and, though all capable of causing us considerable annoyance on slight provocation, seldom give rise to serious trouble or inconvenience. There are,however, a few of these "oversights" which are of little or no known utility, and yet which, either by their structure or situation, may become the starting-point of serious trouble.
The best known members of this small group are the openings through the abdominal wall, which, originally placed at the strongest and safest position in the quadrupedal attitude, are now, in the erect attitude, at the weakest and most dangerous, and furnish opportunity for those serious and sometimes fatal escapes of portions of the intestines which we call hernia; the tonsils; and our friend theappendix vermiformis.
For once its name expresses it exactly. Itisan "appendix," an afterthought; and it is "vermiformis," a worm-like creature,—and, like the worm, will sometimes turn when trodden on. Its worm-likeness is significant in another sense also, in that it is this very diminutiveness in size—the coils into which it is thrown, the spongy thickness of its walls, and the readiness with which its calibre or its circulation is blocked—that is the fundamental cause of its tendency to disease.
The cause of appendicitis is the appendix.
"Despise not the day of small things" is good pathology as well as Scripture. Here we have a little, worm-shaped tag, or side branch, of the food-tube, barely three or four inches long, of about the diameter of a small quill and of a calibre that will barely admit an ordinary knitting needle. And yet we speak of it with bated breath. When we remember that this little, twisted, blind tube opens directly out of one of the largest pouches of the intestines (thecæcum), and that itis easy for anything that may be present in the large pouch—food, irritating fragments of waste matter, or bacteria—to find its way into this fatal little trap, but very difficult to find the way out again, we can form some idea of what a literal death-trap it may become.
How did such a useless and dangerous structure ever come to develop in a body in which for the most part there is mutual helpfulness, utility, and perfect smoothness of working through all the great machine? To attempt to answer this would carry us very far back into ancient history. But to make such backward search is absolutely the only means of reaching an answer.
"But," some one will object, "how perfectly irrational, not to say absurd, to propose to go back hundreds of thousands of years into ancient history, to account for a disease which has been discovered—according to some, invented—within the past twenty-five years!"
Appendicitis is a mark, not a result, of a high grade of civilization. To have had an operation for it is one of the insignia of modern rank and culture. Our new biologic aristocracy, the "Appendix-Free," look down with gentle disdain upon their appendiciferous fellows who still bear in their bodies this troublesome mark of their lowly origin. In short, the general impression prevails that appendicitis is a new disease, a disease which has become common, or perhaps occurred at all, only within the last quarter of a century, and which therefore—with the usual flying leap of popular logic—is a serious menace to our future, if it keeps on increasing in frequency and ferocity at anything like the same rate which it has apparently shown for the past fifteen years.
As this feeling of apprehension is in many minds quite genuine, it may be well to say briefly, before proceeding further, first, that, if there be any disease which absolutely and almost exclusively depends upon definite peculiarities of structure, it is appendicitis, and that these structural peculiarities of this tiny, cramped tag of the food-canal have existed from the earliest infancy of the race. So it is almost unthinkable that man should not have been subject to fatal disturbances of this organ from the very earliest times. On the post-mortem table, the appendix of the lowest savage is the same useless, shriveled, and inflammable worm as that of the most highly civilized Aryan, though perhaps an inch or so longer. Secondly, there is absolutely no adequate proof that appendicitis is increasing in frequency among civilized races. It is only about twenty-five years ago that it was first definitely described, and barely fifteen that the profession began at all generally to recognize it.
But all of us whose memory extends backward a quarter of a century can clearly recall that, while we did not see any cases of "appendicitis," we saw dozens of cases of "acute enteritis," "idiopathic (self-caused) peritonitis," "acute inflammation of the bowels," "acute obstruction of the bowels," of which patients died both painfully and promptly, and which we now know were really appendicitis.
In short, from a careful study of all the data, including the claims so frequently made of freedom from appendicitis on the part of Oriental races, colored races, less civilized tribes, vegetarians, and others, we are tending toward the conclusion that the percentage of appendicitis in a given community is simply the percentage of its recognition,—in other words, of the intelligence and alertness, first of its physicians, and then of its laity. As an illustration, my friend Dr. Bloodgood kindly had the statistics of the surgical patients treated in the great Johns Hopkins Hospital at Baltimore investigated for me, and found almost precisely the same percentage of cases of appendicitis among colored patients as among white patients.
The earlier impression, first among physicians and now in the laity, that appendicitis is an almost invariably fatal disease, is not well founded, and we now know that a large percentage of cases recover, at least from the first attack; so that it is quite possible for from half to two-thirds of the cases of appendicitis actually occurring in a given community to escape recognition, unless promptly reported, carefully examined, and accurately diagnosed. Thirdly, in spite of the remarkable notoriety which the disease has attained, the general dread of its occurrence,—which has been recently well expressed in a statement that everybody either has had it, or expects to have it, or knows somebody who has had it,—the actual percentage of occurrence of grave appendicitis is small. In the United States census of 1900, which was the first census in which it was recognized as a separate cause of death, it was responsible for only 5000 deaths in theentire United States for the ten years preceding, or about one death in two hundred. This rate is corroborated by the data, now reaching into thousands, from the post-mortem rooms of our great hospitals, which report an average of between a half and one per cent. A disease which, in spite of the widespread terror of it, kills only one in two hundred of those who actually die—or about one in every ten thousand of our population—is certainly nothing to become seriously excited over from a racial point of view.
While appendicitis is one of the "realest" and most substantial of diseases, and, in its serious form, highly dangerous to life, there can be little doubt that there has come, first of all, a state of mind almost approaching panic in regard to it; and, second, a preference for it as a diagnosis, as so much moredistinguéthan such plebeian names as "colic," "indigestion," "enteritis," or the plain old Saxon "belly-ache," which has reached almost the proportions of a fad. It is certain that nowadays physicians have almost as frequently to refuse to operate on those who are clamoring for the distinction, as to urge a needed operation upon those unwilling to submit to it.
The satirical proposal that a "closed season" should be established by law for appendicitis as for game birds, during which none might be taken, would apply almost as often to the laity as to the profession, even the surgical half.
Since the chief cause of appendicitis is the appendix, the first question for disposal is, How did the appendix become an appendix? To this biology can render afairly satisfactory answer. It is the remains of one of Mother Nature's experiments with her 'prentice hand upon the mammalian food-tube. As is now generally known, the food-canal in animals was originally a comparatively straight tube, running the length of the body from mouth to anus. It early distends into a moderate pouch, about a third of the way down from the mouth, forming astomach, or storage and churning-place for the food. Below this, it lengthens into coils (the so-calledsmall intestine), which, as the body becomes more complex, increase in number and length until they reach four to ten times the length of the body. Later, the lower third of the tube distends and sacculates out into a so-calledlarge intestine, in which the last remnants of nutritive material and of moisture are extracted from the food-residues before they are discharged from the body. Just at the junction of this large intestine with the small intestine, nature took it into her head to develop a second pouch, a sort of copy of the stomach. This pouch, from the fact that it ends in a blind sac, is known as thecæcum(or "blind" pouch), and is apparently simply a means of delaying the passage of the foodstuffs until all the nutriment and moisture have been absorbed out of them for the service of the body. Naturally, it has developed to the largest degree and size in those animals which have lived upon the bulkiest and grassiest of foods, the so-calledHerbivora, or grass-eaters. In theCarnivora, or flesh-eaters, it is usually small, and in one family, the bears, entirely absent. This pouch is no mere figure of speech, as may be gathered from the fact that incertain of the rodentHerbivora, like the common guinea-pig, it may have a capacity equal to all of the rest of the alimentary canal, and in the horse it will hold something like four times as much as the stomach. Oddly enough, among the grass-eaters, for some reason which we do not understand, it appears to occur in a sort of inverse proportion to the stomach; those which have large, sacculate, pouched stomachs, like the cow, sheep, and the ruminants generally, having smallercæca. In otherHerbivorawith small stomachs, like the rabbit and the horse, it develops greater size.
Our primitive ancestors were mixed feeders, and, though probably more largely herbivorous than we are to-day, had a medium-sizedcæcum, and maintained it up to the point at which the anthropoid apes began to branch off from our family-tree. But at about this point, for some reason, possibly connected with the increasing variety and improved quality and concentration of the food, due to greater intelligence and ability to obtain it, this largecæcumbecame unnecessary, and began to shrivel.
Here, however, is where nature makes her first afterthought mistake. Instead of allowing this pouch to contract and shrivel uniformly throughout its entire length, she allowed the farther (ordistal) two-thirds of it to shrivel down at a much faster rate than the central (orproximal) third; so that the once evenly distended sausage-shaped pouch, about six to eight inches long and two inches in diameter, has become distorted down into a narrow, contracted end portion, about a quarter of an inch in diameter, and a distended first portion,for all the world like a corncob pipe with a crooked stem and an unusually large bowl. And behold—the modernappendix vermiformis, with all its fatal possibilities!
If we want something distinctly human to be proud of, we may take the appendix, for man is the only animal that has this in its perfection. A somewhat similarly shriveled last four inches of thecæcumis found in the anthropoid apes and in the wombat, a burrowing marsupial of Australia. In some of the monkeys, and in certain rodents like the guinea-pig, a curious imitation appendix is found, which consists simply of a contracted last four or five inches of thecæcum, which, however, on distention with air, is found to relax and expand until of the same size as the rest of the gut.
The most strikingly and distinctly human thing about us is not our brain, but our appendix. And, while recognizing its power for mischief, it is only fair to remember that it is an incident and a mark of progress, of difficulties overcome, of dangers survived. In all probability, it was our change to a more carnivorous diet, and consequently predatory habits, which enabled our ancestors to step out from the ruck of the "Bandar-Log," the Monkey Peoples. An increase in carnivorousness must have been a powerful help to our survival, both by widening our range of diet, so that we could live and thrive on anything and everything we could get our hands on, and by inspiring greater respect in the bosoms of our enemies. Let us therefore respect the appendix as a mark and sign of historicprogress and triumph, even while recognizing to the full its unfortunate capabilities for mischief.
But what has this ancient history to do with us in the twentieth century? Much in every way. First, because it furnishes the physical basis of our troubles; and second, and most important, because, like other history, it is not merely repeating itself, but continuing. This process of shriveling on the part of the appendix is not ancient history at all, but exceedingly modern; indeed, it is still going on in our bodies, unless we are over sixty-five years of age.
In the first place, we have actually passed through two-thirds of this process in our own individual experience.
At the first appearance of thecæcum, or blind pouch, in our prenatal life, it is of the same calibre as the rest of the intestine, and of uniform size from base to tip. About three weeks later the tip begins to shrivel, and from this on the process steadily continues, until at birth it has contracted to about one-fifteenth of the bulk of thecæcum. But the process doesn't stop here, though its progress is slower. By about the fifth year of life the stem of the cæco-appendix pipe has diminished to about one-thirtieth of the size of the bowl, which is the proportion that it maintains practically throughout the rest of adult life. For a long time we concluded that the process was here finished, and that the appendix underwent no further spontaneous changes during life; but, after appendicitis became clearly recognized, a more careful study was made of the condition of the appendix in bodies coming to thepost-mortem table, dead of other diseases, at all ages of life. This quickly revealed an extraordinary and most significant fact, that, while the appendix was no longer decreasing in apparent size, its internal capacity or calibre was still diminishing, and at such a rate that by the thirty-fifth year it had contracted down so as to become cut off from the cavity of thecæcumin about twenty-five to thirty per cent of all individuals. By the forty-fifth year, according to the anatomist Ribbert (who has made the most extensive study of the subject), nearly fifty per cent of all appendices are found to be cut off, and by the sixty-fifth year nearly seventy per cent.
This explains at once why appendicitis is so emphatically a disease of young life, the largest number of cases occurring before the twenty-fifth year (fifty per cent of all cases occur between ten and thirty years of age), and becoming distinctly rarer after the thirty-fifth, only about twenty per cent occurring after this age. As soon as the cavity of the appendix is cut off from that of the intestine, it is of course obvious that infectious or other irritating materials can no longer enter its cavity to cause trouble, although, of course, it is still subject to accidents due to kinks, or twists, or interference with its blood-supply; but these are not so dangerous, providing there be no infectious germs present.
Here, then, we have a clear and adequate physical basis for appendicitis. A small, twisted, shriveling spur or side twig of the intestine, opening from a point which has become a kind of settling basin in the food-tube,its mouth gaping, as it were, to admit any poisonous or irritating food, infectious materials, disease-germs, the ordinary bacteria which swarm in the alimentary canal, or irritating foreign bodies, like particles of dirt, sand, hairs, fragments of bone, pins, etc., which may have been accidentally swallowed. Once these irritating and infectious materials have entered it, spasm of its muscular coat is promptly set up, their escape is blocked, and a violent inflammation easily follows, which may end in rupture, perforation, or gangrene.
Not only may any infection which is sweeping along the alimentary canal, thrown off and resisted by the vigorous, full-sized, well-fed intestine, find a point of lowered resistance and an easy victim for its attack in the appendix, but there is now much evidence to indicate that the ordinary bacteria which inhabit the alimentary canal, particularly that first cousin of the typhoid bacillus, the colon bacillus, when once trapped in thiscul-de-sac, may quickly acquire dangerous powers and set up an acute inflammation. It is not necessary to suppose that any particular germ or infection causes appendicitis. Any one which passes through, or attacks, the alimentary canal is quite capable of it, and probably does cause its share of the attacks.
Numerous attempts have been made to show that appendicitis is particularly likely to follow typhoid fever, rheumatism, influenza, tonsilitis, and half a dozen other infectious or inflammatory processes. But about all that has been demonstrated is that it may follow any of them, though in none with sufficient frequency or constancy to enable it to be regarded asone of the chief or even one of the important causes of the disease.
One dread, however, we may relieve our anxious souls of, and that is the famous grape-seed or cherry-stone terror. To use a Hibernianism, one of our most positive conclusions in regard to the cause of appendicitis is a negative one: that it is not chiefly, or indeed frequently, due to the presence of foreign bodies. This was a most natural conclusion in the early days of the disease, since, given a tiny blind pouch with a constricted opening gaping upon the cavity of the food-canal, nothing could be more natural than to suppose that small irritating food remnants or foreign bodies, slipping into it and becoming lodged, would block it and give rise to serious inflammation. And, moreover, thisa prioriexpectation was apparently confirmed by the discovery, in many appendices removed by operation, of small oval or rounded masses, closely resembling the seed of some vegetable or fruit. Whereupon anxious mothers promptly proceeded to order their children to "spit out," with even more religious care than formerly, every grape-seed and cherry-stone. The increased use of fresh and preserved fruits was actually gravely cited, particularly by our Continental brethren, as one of the causes of this new American disease. Barely ten years ago I was spending the summer in the Adirondacks, and was bitterly reproached by the host of one of the Lake hotels, because the profession had so terrified the public about the dangers of appendicitis from fruit-seeds that he was utterly unable to serve upon his tables a large stock of delicious preserved and canned raspberries, blackberries, and grapes which he had put up the previous years. "Why," he said, "more than half the people that come up here will no more eat them than they would poison, for fear that some of the seeds will give 'em appendicitis." This dread, however, has been deprived of all rational basis, first, by finding that many inflamed appendices removed, after the operation became more common, contained no foreign body whatever; secondly, that many perfectly healthy appendices examined on the post-mortem table, death being due to other diseases, contain these apparently foreign bodies; and thirdly, that when these "foreign bodies" were cut into, they were found to be not seeds or pits of any description, but hardened and, in some cases, partially calcareous masses of the fæces.
We are in a nearly similar position in regard to the third alleged cause of appendicitis, and that is food. Many are the accusations which have been made in this field. On the one hand, meat and animal foods generally have been denounced, on account of their supposed "heating" or "uric-acid-forming" properties; while on the other, vegetables and fruits have been equally hotly incriminated, on account of their seeds, fibres, husks, and irritating substances, and the danger of their being contaminated by bacteria and other parasites from the soil. These charges appear to have little adequate foundation, and, so far as we are in a position now to judge, the only way a food can give, or be accessory to, appendicitis is by its being taken in such excessive amounts as to set up fermentive or putrefactive changes in the alimentary canal, or by its being in an unsound, decaying, or actually diseased condition. Any amounts or quality of food which are capable of giving rise to an attack of acute indigestion may secondarily lead to an attack of appendicitis. The only single article of diet whose ingestion is declared by Osler to be rather frequently followed by an attack of appendicitis is the peanut.
Therefore, the best thing to do in the way of taking precautions against the occurrence of appendicitis is, in the language of the day, to "forget it" as completely as possible, reassuring ourselves that, in spite of its extraordinary notoriety and popularity, it is a comparatively rare disease in its fatal form, responsible for not more than one-half of one per cent of the deaths, and that the older we grow, the better become our chances of escaping it.
Whatever we may have decided in regard to our brains, by the time we reach fifty, we may feel reasonably sure we've no appendix.
But the question will at once arise, if the appendix be so tiny in size, so insignificant in capacity, and so devoid of useful function, what is the use of disturbing ourselves over the question of what may become of it? If it is going to decay and drop off, why not permit it to do so, with the philosophic indifference with which we would sacrifice the tip of our little fingers in a planing-mill? Here, however, is just the rub, and the fact that gives to appendicitis all its terrors, and to the question of what to do in each particular case its difficulties and perplexities.
The appendix does not, unfortunately, hang out from the surface of the body, where it could peacefully decay and drop off without prejudice to the rest of the body, or be quickly lopped off in the event of its giving trouble. On the contrary, it projects its stubby and insignificant length right into the midst of the most delicate and susceptible cavity of the body, the general cavity of the abdomen, or peritoneum. The thin, sensitive sheet of peritoneum which lines this cavity covers every fold and part of the food-tube, from the stomach down to the rectum. And when once infection or inflammation has occurred at any point in it, there is nothing to prevent its spreading like a prairie fire, all over the entire abdominal cavity from diaphragm to pelvis. If this wretched little remnant were a coil of explosive fuse within the brain-cavity itself, which any jar might set off, it could hardly be richer in possibilities of danger.
A redeeming feature of appendicitis is that the appendix lies—so to speak—in a corner, or wide-mouthed pouch, of the great peritoneal cavity; and if the inflammation set up in it can be "walled off" from the rest of the peritoneal cavity, and limited strictly to this little corner or pouch, all will be well. This is what occurs in those cases of severe appendicitis which spontaneously recover. If, however, this disturbance bursts its barriers, and lights up an inflammation of the entire peritoneal cavity, then the result is likely to be a fatal one. Just how far nature can be trusted in each particular case to limit and stamp out the process in this manner is the core of the problem that confronts us, as attending physicians.
In the majority of cases, fortunately, the peritoneal fire brigade acts promptly, pours out a wall of exudate, and locks up the appendix in a living prison, to fight out its own battles and sink or swim by itself. But unfortunately, in a minority of cases, by a wretched sort of "senatorial courtesy" which exists in the body, the appendix is given its ancestral or traditional rights and allowed to inflict its petty troubles upon the entire abdominal cavity, and include the body in its downfall.
Lastly come the two most pertinent and appealing questions:—
What is the outlook for me if I should develop appendicitis? And what is to be done?
In regard to the first of these, it is safe to say that our answer is much less alarming than it was in the earlier stage of our knowledge. Naturally enough, in the beginning, only the severest and most unmistakable forms of the disease and those which showed no tendency to localization, were recognized, or at least came under the eye of the surgeon; and as a large percentage of these resulted fatally, the conclusion was reached, both in the medical profession and by the laity, that appendicitis was an exceedingly dangerous disease, with a high fatality in all cases. As, however, physicians became more expert in the recognition of the disease, it was discovered to be vastly more common, while side by side came the consoling knowledge that a considerable percentage of cases got well of themselves, in the sense of the inflammation being limited to the lower right-hand corner of the abdominal cavity, though, of course, with the possibility ofleaving a smouldering fuse which might light up another explosion under any stress in future.
Further, as the attention of the post-mortem investigators at our large hospitals was directed to the subject, it was found that a very considerable percentage of all bodies, ranging from twenty to—according to some estimates—as high as sixty per cent, showed changes in the appendix and its neighborhood which were believed to be due to old inflammations; so that, while it is possible to speak only with great caution and reserve, the balance of opinion among clinicians and pathologists of wide experience and the more conservative surgeons appears to be that from one-half to two-thirds of all cases of appendicitis will recover of themselves, in the sense of subsiding more or less permanently, without causing death.
On the other hand, it must be remembered that the appendix is an organ which, so far as any evidence has been adduced, is entirely without useful function; that it is in process of shriveling and disappearance, if left entirely alone, and that the best result which can be expected from a self-cured attack of appendicitis is the destruction of the appendix and its elimination as a further possible cause of mischief. By avoiding an operation in appendicitis, we may be practically certain that we save nothing that is worth saving—except the fee. Moreover, even though only from one-fourth to one-third of all cases develop serious complications, you never can be quite sure in which division your particular case will fall.
The situation is in fact a little bit like one relatedin the experience of Edison, the inventor. The trustees of a church in a neighboring town had just completed a beautiful new church building with a high spire, projecting far above any other building in the town. When it was nearing completion, the question arose, should they put on a lightning-rod. The great church itself had strained their financial resources, and one party in the board were of the opinion that they should avoid this unnecessary expense, supporting their economic attitude by the argument that, to put on a lightning-rod, would argue a lack of trust in Providence. Finally, after much debate, it was decided, as the great electrician was readily accessible, to submit the question to him. Mr. Edison listened gravely to the arguments presented, pro and con.
"What is the height of the building, gentlemen?"
The number of feet was given.
"How much is that above that of any surrounding structures?"
The data were supplied.
"It is a church, you say?"
"Yes."
"Well," said the great man, "on the whole, I should advise you to put on a lightning-rod. Providence is apt to be, at times, a trifle absent-minded."
The chances are in favor of your recovery, but—put on a lightning-rod, in the shape of the best and most competent doctor you know, and be guided entirely by his opinion. An attack of appendicitis is like shooting the Grand Lachine Rapids. Probably you will come through all right; but there is always thepossibility of landing at a moment's notice on the rocks or in the whirlpools. With a good pilot your risk doesn't exceed a fraction of one per cent. And fortunately this condition has been not merely theoretically but practically reached already; for the later series of case-groups of appendicitis treated in this intelligent way by coöperation between the physician and surgeon from the start, with prompt interference in those cases which to the practiced eye show signs of making trouble, has reduced the actual recorded mortality of the disease to between two and five per cent. Even of those cases which come to operation now, the death-rate has been reduced as low as five per cent, in series of from 400 to 600 successive operations. When we contrast this with the first results of operation, when the cases as a rule were seen too late for the best time of interference, and from twenty per cent to thirty per cent died; and with the intermediate stage, when surgeons as a rule were inclined to advise operation at the earliest possible moment that the disease could be recognized, and from ten per cent to fifteen per cent died, we can see how steady the improvement has been, and how encouraging the outlook is for the future.
Cases which have weathered one attack of appendicitis are of course by no means free from the risk of another. Indeed, at one time it was believed that a recurrence was almost certain to occur. Later investigations, based upon larger numbers of cases, now running up into the thousands, give the reassuring result that though this danger is a real one, it is not so great as it was at one time supposed, as the averagenumber in whom a second attack occurs appears to be about twenty per cent. This, however, is a large enough risk to be worthy of serious consideration; and in view of the fact that the mortality of operations done between attacks is less than one per cent, it is generally the feeling of the profession that, where there is any appreciable soreness, or tenderness, or liability to attacks of pain in the right iliac region, in an individual who has had one attack of appendicitis, the really conservative and prudent procedure is to have the source of the trouble removed once and for all.
The four principal symptoms of appendicitis are: pain, which is usually felt most keenly somewhere between the umbilicus and the right groin, though this is by no means invariable; tenderness in that same region upon pressure; rigidity of the muscles of the abdominal wall on the right side; and temperature, or fever.
No matter how much and how variegated pain you may have in the abdomen, or how high your temperature may run, if you are not distinctly sore on firm pressure down in this right lower or southwest quadrant of the abdomen,—but be careful not to press too hard, it isn't safe,—you may feel fairly sure that you haven't got appendicitis. If you are, you may still not have it, but you'd better send for the doctor, to be sure.
Malaria has probably killed more human beings than all the wars that have ever devastated the globe. Some day the epic of medicine will be written, and will show what a large and unexpected part it has played in the progress of civilization. Valuable and essential to that progress as were the classic great discoveries of fire, ships, wheeled carriages, steam, gunpowder, and electricity, they are almost paralleled by the victories of sanitary science and medicine in the cure and prevention of that greatest disrupter of the social organism—disease. No sooner does the primitive human hive reach that degree of density which is the one indispensable condition of civilization, than it is apt to breed a pestilence which will decimate and even scatter it. Smallpox, cholera, and bubonic plague have blazed up at intervals in the centres of greatest congestion, to scourge and shatter the civilization that has bred them. No civilization could long make headway while it incurred the dangers from its own dirtiness; and to-day the most massive and imposing remains of past and gone empires are their aqueducts, their sewers, and their public baths. What chance has a community of building up a steady and efficient working force, or even an army largeenough for adequate defense, when it has a constant death-rate of ten per cent per annum, and an ever recurrent one of twenty to thirty per cent, by the sweep of some pestilence? The bubonic plague alone is estimated to have slain thirty millions of people within two centuries in Mediæval Europe, and to have turned whole provinces into little better than deserts.
In malaria, however, we have a disease enemy of somewhat different class and habits. While other great infections attack man usually where he is strongest and most numerous, malaria, on the contrary, lies in wait for him where he is weakest and most scattered, upon the frontiers of civilization and the borders of the wilderness. It is only of late years that we have begun to realize what a deadly and persistent enemy of the frontiersman and pioneer it is. We used to hear much of climate as an obstacle to civilization and barrier to settlement. Now, for climate we read "malaria." Whether on the prairies or even the tundras of the North, or by the jungles and swamps of the Equator, thething that killedwas eight times out of ten the winged messenger of death with his burden of malaria-infection. The "chills and fever," "fevernager," "mylary," that chattered the teeth and racked the joints of the pioneer, from Michigan to Mississippi, was one and the same plague with the deadly "jungle fever," "African fever," "black fever" of the tropics, from Panama to Singapore. Hardly a generation ago, along the advancing front of civilization in the Middle West, the whole life of the community was colored with a malarial tinge and the taste of quinine wasas familiar as that of sugar. To this day, over something like three-quarters of the area of these United States, the South, Middle West, and Far West, if you feel headachy and bilious and "run down," you sum it all up by saying that you are feeling "malarious." Dwellers upon the rich bottom-lands expected to shake every spring and fall with almost the same regularity as they put on and shed their winter clothing. Readers of Frank Stockton will remember the gales of merriment excited by his quaint touch of the incongruous in making the prospective bridegroom of the immortal Pomona change the date of their wedding day from Tuesday to Monday, because, on figuring the matter out, he had discovered that Tuesday was his "chill-day."
Though the sufferer from ague seldom received very much sympathy at the time, but was considered a fair butt for genial ridicule and chaff, yet even there the trouble had its serious side. Through all those communities there stalked a well-known and dreaded spectre, the so-called "congestive chill," what is now known in technical language as the pernicious malarial paroxysm. These were like the three warnings of death in the old parable. You would probably survive the first and might never have another; but if you had your second, it was considered equivalent to a notice to quit the country promptly and without counting the cost. In my boyhood days in the Middle West, I can recall hearing old pioneers tell of little groups of one or more families moving out on to some particularly rich and virgin bottom-land and losing two or threeor more members out of each family by congestive chills within the first year, and in some cases being driven in from the outpost and back to civilization by the fearful death-loss.
A pall of dread hangs over the whole west coast of Africa. The factories and trading-posts are haunted by the ghosts of former agents and explorers who have died there. Some years ago one German company had the sinister record that of its hundreds of agents sent out to the Gold Coast under a three years' contract, not one had fulfilled the term! All had either died, or been invalided and returned home. It was malaria more than any other five influences combined that thwarted the French in their attempt to dig the Panama Canal and that made the Panama Railroad bear the ghastly stigma of having built its forty miles of track with a human body for every tie.
Malaria ever has been, and is yet, the great barrier against the invasion of the tropics by the white races; nor has its injurious influence been confined to the deaths that it causes, for these gaps in the fighting line might be filled by fresh levies drawn from the wholesome North. Its fearfully depressing and degenerating effects upon even those who recover from its attacks have been still more injurious. It has been held by careful students of tropical disease and conditions that no small part of that singular apathy and indifference which steal over the mind and body of the white colonist in the tropics, numbing even his moral sense, and alternating with furious outbursts of what the French have termed "tropical wrath,"characterized by unnatural cruelty and abnormal disregard for the rights of others, is the deadly work of malaria. It is the most powerful cause, not merely of the extinction of the white colonist in the tropics, but of the peculiar degeneracy—physical, mental, and moral—which is apt to steal over even the survivors who succeed in retaining a foothold. Two particularly ingenious investigators have even advanced the theory that the importation of malaria into the islands of Greece and the Italian peninsula by soldiers returning from African and Southern Asiatic conquests had much to do with accelerating, if not actually promoting, the classic decay of both of these superb civilizations.
To come nearer home, there can be little question that the baneful, persistent influence of malaria, together with the hookworm disease, has had much to do both with the degeneracy of the Southern "cracker," or "mean white," and with those wild outbursts of primitive ferocity in all classes which take the form of White Cap raids and lynching mobs.
However this may be, the disease and the colonization habit brought in a crude way their own remedy. The Spanish conquerors of Peru were told by the natives that a certain bark which grew upon the slopes of the Andes was a sovereign remedy for those terrible ague seizures. Indian remedies did not stand as high in popular esteem as they do now; but they were in desperate straits and jumped at the chance. To their delight, it proved a positive specific, and a Spanish lady of rank, the Countess Chincona, was so delightedwith her own recovery that she carried back a package of the precious Peruvian bark on her return to Europe, and endeavored to introduce it. So furious was the opposition of the Church, however, to this "pagan" remedy that she was completely defeated in her praiseworthy attempt and was obliged to confine her ministrations to those who belonged to her, the peasantry on her own estate. About half a century later, the new remedy excited so much discussion by the numerous cures that it effected, that it was considered worthy of a special council of the Jesuits, who formally pronounced it suitable for the use of the faithful, thereby attaching to it for many years the name of "Jesuit's bark." Virtue, however, is sometimes rewarded in this world, and the devoted and enlightened countess has, all unknown to herself, attained immortality by attaching her name, Chincona, softened intocinchona, and hardened intoquinine, to the greatest therapeutic gift of the gods to mankind. It is not too much to say that the modern colonization of the tropics and subtropics by Northern races, which is one of the greatest and most significant triumphs of our civilization, would have been almost impossible without it. Its advance depended upon two powders, one white and the other black,—quinine and gunpowder.
For nearly three centuries we rested content with the knowledge that in quinine we had a remedy for malaria, which, if administered at the proper time and in adequate doses, would break up and cure ninety per cent of all cases. Just how it did it we were utterly in the dark, and many were the speculations that were indulged in. It was not until 1880, that Laveran, a French army surgeon stationed in Algeria, announced the discovery in the blood of malarial patients of an organism which at first bore his name, theHematozoon-Laveran, now known as thePlasmodium malariæ. This organism, of all curious places, burrowed into and found a home in the little red corpuscles of the blood. At periods of forty-eight hours it ripened a crop of spores, and would burst out of the corpuscles, scattering throughout the blood and the tissues of the body, and producing the famous paroxysm. This accounted for the most curious and well-marked feature of the disease, namely, its intermittent character, chill and fever one day, and then a day of comparative health, followed by another chill day and so on, as long as the infection continued. One problem, however, was left open, and that was why certain forms of the disease had their chills every fourth day and so were calledquartanague. This was quickly solved by the discovery of another form of the organism, which ripened its spores in three days instead of two. So the whole curious rhythm of the disease was established by the rate of breeding or ripening of the spores of the organism. Later still another form was discovered, which had no such regular period of incubation and gave rise to the so-called irregular, orautumnal, malarial fevers. That form of the fever which had a paroxysm every day, the classicquotidianague, remained a puzzle for a little longer, but was finally discovered to be due chiefly to the presence of two broods, or infections, of the organism, which ripened onalternate days and hence kept the entire time of the unfortunate patient occupied.
The mystery of the remedial effect of quinine was also solved, as it was found that, if administered at the time which centuries of experience has shown us to be the most effective, between or shortly before the paroxysms, it either prevented sporulation or killed the spores. So that at one triumphant stroke the mystery of centuries was cleared up.
But here will challenge some twentieth-centuryGradgrind: "This is all very pretty from the point of view of abstract science, but what is the practical value of it? The discovery of the plasmodium and its peculiarities has merely shown us the how and the why of a fact that we had known well and utilized for centuries, namely, that quinine will cure malaria." Just listen to what follows. The story of the plasmodium is one of the most beautiful illustrations of the fact that there is no such thing as useless or unpractical knowledge. The only thing that makes any knowledge unpractical is our more or less temporary ignorance of how to apply it. The first question which instantly raised itself was, "How did the plasmodium get into human blood?" The very sickle-shape of the plasmodium turned itself into an interrogation mark. The first clew that was given was the new and interesting one that this organism was a new departure in the germ line in that it was an animal, instead of a plant, like all the other hitherto known bacilli, bacteria, and other disease-germs.
It may be remarked in passing that its discoveryhad another incidental practical lesson of enormous value, and that was that it paved the way for the identification of a whole class of animal parasites causing infectious diseases, which already includes the organisms of Texas fever in cattle, dourine in horses, thetsetsefly disease, the dreaded sleeping sickness, and finally such world-renowned plagues as syphilis and perhaps smallpox.
Being an animal, the plasmodium naturally would not grow upon culture-media like the vegetable bacilli and bacteria, and this very fact had delayed its recognition, but raised at once the probability that it must be conveyed into the human body by some other animal. Obviously, the only animals that bite our human species with sufficient frequency and regularity to act as transmitters of such a common disease are those Ishmaelites of the animal world, the insects. As all the evidence pointed toward malaria being contracted in the open air, attested by its popular though unscientific namemal-aria, "bad air," and as of all forms of "bad air" the night air was incomparably the worst, it must be some insect which flew and bit by night; which by Sherlock Holmes's process promptly led the mosquito into the dock as the suspected criminal. It wasn't long before he was, in the immortal language of Mr. Devery, "caught with the goods on"; and in 1895 Dr. Ronald Ross, of the Indian Medical Service, discovered and positively identified the plasmodium undergoing a cycle of its development in the body of the mosquito. He attempted to communicate the disease to birds andanimals by allowing infected mosquitoes to bite them, but was unsuccessful. Two Italian investigators, Bignami and Grassi, saw that the problem was one for human experiment and that nothing less would solve it. Volunteers were called for and promptly offered themselves. Their blood was carefully examined to make sure that they were not suffering from any latent form of malaria. They then allowed themselves to be bitten by infected mosquitoes, and within periods varying from six to ten days, eight-tenths of them developed the disease. It may be some consolation to our national pride to know that although the organism was first identified in the mosquito by an Englishman and its transmission to human beings in its bite by Italians, the first definite and carefully worked-out statement of the relation of the mosquito to malaria was made by an American, King of Washington, in 1882; though it is only fair to say that suggestions of the possible connection between mosquitoes and malaria had, so to speak, been in the air and been made from scores of different sources, from the age of Augustus onward.
Another mystery was solved—and what a flood of light it did pour upon our speculations as to the how and wherefore of the catching of malaria! In some respects it curiously corroborated and increased our respect for popular beliefs and impressions. While "bad air" had nothing to do with causing the disease, except in so far as it was inhabited by songsters of theAnophelesgenus, yet it was precisely the air of marshy places which was most likely to be "bad" in this sense.So that, while in one sense those local wiseacres, who would point out to you the pearly mists of evening as they rose over low-lying meadows and bottom-lands, and inform you that there before your very eyes was the "mylary just a-risin' out of the ground," were ludicrously mistaken, in another their practical conclusion was absolutely sound; for it is in just such air, at such levels above the surface of the water, that theAnophelesmost delights to disport himself. Furthermore, while all raw or misty air is "bad," the night air is infinitely more so than that of the day, because this is the time at which mosquitoes are chiefly abroad. In fact, there can be little doubt that this is part of the foundation for that rabid and unreasonable dread of the night air which we fresh-air crusaders find the bitterest and most tenacious foe we have to fight. We have literally discovered the Powers of Darkness in both visible and audible form, and they have wings and bite, just like the vampire.
It was also a widespread belief in malarial regions that the hours when you are most likely to "git mylary inter yer system" were those just before and just after sundown; and now entomologists inform us that these are precisely the hours at which theAnophelesmosquito, the only genus that carries malaria, flies abroad.
Of course, a number of popular causes, such as bad drainage, the drinking of water from shallow surface wells, damp subsoils under the houses, and especially that peculiarly widespread and firmly held article of belief that new settlements, where large areas of prairie sod were being freshly upturned by the plough,were peculiarly liable to the attack and spread of malaria, had to go by the board,—with this important reservation, however, that almost every one of these alleged causes either implied or was pretty safe to be associated with pools or swamps of stagnant water in the neighborhood, which would furnish breeding-spots for the mosquitoes.
The discovery explains at once a score of hitherto puzzling facts as to the distribution of malaria. Why, for instance, in all tropical or other malarious countries, those who slept in second and third story bedrooms were less likely to contract the disease, supposedly because "bad air didn't rise to that height," is clearly seen to be due to the fact that the mosquito seldom flies more than ten or twelve feet above the level of the ground or marsh in which he breeds, except when swept by prevailing winds. It also explained why in our Western and Southwestern states the inhabitants of the houses situated on the south bank of a river, though but a short distance back from the stream, would suffer very slightly from malaria, while those living upon the north bank, half a mile back, or even upon bluffs fifteen or twenty feet above the water level, were simply plagued with it. The prevailing winds during the summer are from the south and mosquitoes cannot fly a foot against the wind, but will fly hundreds of yards, and even the best part of a mile, with it. The well-known seasonal preference of the disease for warm spring and summer months, and its prompt subsidence after a killing frost, were seen simply to be due to the influence of the weather uponthe flight of mosquitoes. Shakespeare's favorite reference to "the sun of March that breedeth agues" has been placed upon a solid entomological basis by the discovery that, like his pious little brother insect, the bee, the one converted and church-going member of a large criminal family, the mosquito hies himself abroad on his affairs at the very first gleam of spring sunshine, and will even reappear upon a warm, sunny day in November or December. Perhaps even some of the popular prejudice against "unseasonable weather" in winter may be traceable to this fact.
Granted that mosquitoes do cause and are the only cause of malaria, what are you going to do about it? At first sight any campaign against malaria which involves the extermination of the mosquito would appear about as hopeless as Mrs. Partington's attempt to sweep back the rising Atlantic tide with her broom. But a little further investigation showed that it is not only within the limits of possibility, but perfectly feasible, to exterminate malaria absolutely from the mosquito end. In the first place, it was quickly found that by a most merciful squeamishness on the part of the plasmodium, it could live only in the juices of one particular genus of mosquito, theAnopheles; and as nowhere, not even in the most benighted regions of Jersey, has this genus been found to form more than about four or five per cent of the total mosquito population, this cuts down our problem to one-twentieth of its apparent original dimensions at once. The ordinary mosquito of commerce (known asCulex) is anynumber of different kinds of a nuisance, but she does not carry malaria.
Here the trails of the extermination party fork, one of them taking the perfectly obvious but rather troublesome direction of protecting houses and particularly bedrooms with suitable screens and keeping the inhabitants safely behind them from about an hour before sundown on. By this simple method alone, parties of explorers, of campers, of railroad-builders going through swamps, of the laborers on our Panama Canal, have been enabled to live for weeks and months in the most malarious regions with perfect impunity, so long as these precautions were strictly observed. The first experiment of this sort was carried out by Bignami upon a group of laborers in the famous, or rather infamous, Roman Campagna, whose deadly malarial fevers have a classic reputation, and has achieved its latest triumphs in the superb success of Colonel Gorgas at Panama. While this procedure should never be neglected, it is obvious that it involves a good deal of irksome confinement and interferes with freedom of movement, and it will probably be carried out completely only under military or official discipline, or in tropical regions where the risks are so great that its observance is literally a matter of life or death.
The other division of malaria-hunters pursued the trail of theAnophelesto her lair. There they discovered facts which give us practically the whip-hand over malarial and other tropical fevers whenever we choose to exercise it. It had long been known that the breeding-place of mosquitoes was in water; that their eggs whendeposited in water floated upon the surface like tiny boats, usually glued together into a raft; that they then turned into larvæ, of which the well-known "wigglers" in the water-butt or the rain-barrel are familiar examples; and that they finally hatched into the complete insect and rose into the air.
Obviously, there were two points at which the destroyers might strike, the egg and the larvæ. It was first found that, while the eggs required no air for their development, the larvæ wiggled up to the surface and inhaled it through curious little tubes developed for this purpose, oddly enough from their tail-ends. If some kind of film could be spread over the surface of the water, through which the larvæ could not obtain air, they would suffocate. The well-known property of oil in "scumming over" water was recalled, two or three stagnant pools were treated with it, and to the delight of the experimenters, not a single larva was able to develop under the circumstances. Here was insecticide number one. The cheapest of oils, crude petroleum, if applied to the pool or marsh in which mosquitoes breed, will almost completely exterminate them. Scores of regions and areas to-day, which were once almost uninhabitable on account of the plague of mosquitoes, are now nearly completely free from these pests by this simple means. An ounce to each fifteen square feet of water-surface is all that is required, though the oiling needs to be repeated carefully several times during the season.
But what of the eggs? They require no air, and it was found impossible to poison them without simplysaturating the water with powerful poisons; but an unexpected ally was at our hand. It was early noted that mosquitoes would not breed freely in open rivers or in large ponds or lakes, but why this should be the case was a puzzle. One day an enthusiastic mosquito-student brought home a number of eggs of different species, which he had collected from the neighboring marshes, and put them into his laboratory aquarium for the sake of watching them develop and identifying their species. The next morning, when he went to look at them, they had totally disappeared. Thinking that perhaps the laboratory cat had taken them, and overlooking a most contented twinkle in the corner of the eyes of the minnows that inhabited the aquarium, he went out and collected another series. This time the minnows were ready for him, and before his astonished eyes promptly pounced on the raft of eggs and swallowed them whole. Here was the answer at once: mosquitoes would not develop freely where fish had free access; and this fact is our second most important weapon in the crusade for their extermination. If the pond be large enough, all that is necessary is simply to stock it with any of the local fish, minnows, killies, perch, dace, bass,—and presto! the mosquitoes practically disappear. If it be near some larger lake or river containing fish, then a channel connecting the two, to allow of its stocking, is all that is required.
On the Hackensack marshes to-day trenches are cut to let the water out of the tidal pools; while in low-lying areas, which cannot be thus drained, thecentral lowest spot is selected, a barrel is sunk at this spot, and four or five "killie" fish are placed in it. Trenches are cut converging into this barrel from the whole of the area to be drained, and behold, no more mosquitoes can breed in that area, and, in the language of the day, "get away with it."
Finally, most consoling of all, it was discovered that, while the ordinaryCulexmosquito can breed, going through all the stages from the egg to the complete insect, in about fourteen days, so that any puddle which will remain wet for that length of time, or even such exceedingly temporary collections of water as the rain caught in a tomato-can, in an old rubber boot, in broken crockery, etc., will serve her for a breeding-place, theAnopheleson the other hand takes nearly three months for the completion of her development. So that, while a region might be simply swarming with ordinary mosquitoes, it would frequently be found that the only places which fulfilled all the requirements for breeding-homes for theAnopheles, that is, isolation from running water or larger streams, absence of fish, and persistence for at least three months continuously, would not exceed five or six to the square mile. Drain, fill up, or kerosene these puddles,—for they are often little more than that,—and you put a stop to the malarial infection of that particular region. Incredible as it may seem, places in such a hotbed of fevers as the west coast of Africa, which have been thoroughly investigated, drained, and cleaned up by mosquito-brigades, have actually been freed from further attacks of fever by draining andfilling not to exceed twenty or thirty of these breeding-pools.
In short, science is prepared to say to the community: "I have done my part in the problem of malaria. It is for you to do the rest." There is literally no neighborhood in the temperate zone, and exceedingly few in the tropics, which cannot, by intelligent coöperation and a moderate expense, be absolutely rid first of malaria, and second of all mosquito-pests. It is only a question of intelligence, coöperation, and money. The range of flight of the ordinary mosquito is seldom over two or three hundred yards, save when blown by the wind, and more commonly not more than as many feet, and thorough investigation of the ground within the radius of a quarter of a mile of your house will practically disclose all the danger you have to apprehend from mosquitoes. It is a good thing to begin with your own back yard, including the water-butt, any puddles or open cesspools or cisterns, and any ornamental water gardens or lily-ponds. These latter should be stocked with fish or slightly oiled occasionally. If there be any accumulations of water, like rain-barrels or cisterns, which cannot be abolished, they should either be kept closely covered or well screened with mosquito netting.
It might be remarked incidentally in passing, that the only really dangerous sex in mosquitodom, as elsewhere, is the female. The male mosquito, if he were taxed with transmitting malaria, would have a chance to reëcho Adam's cowardly evasion in the Garden of Eden, "It was the woman that thou gavestme." Both sexes of mosquitoes under ordinary conditions are vegetable feeders, living upon the juices of plants. But when the female has thrown upon her the tremendous task of ripening and preparing her eggs for deposition, she requires a meal of blood—which may be a comfort to our vegetarian friends, or it may not. Either she requires a meal of blood to nerve her up to her criminal deed, or, when she has some real work to do, she has to have some real food.
The mosquito-brigade have still another method of checking the spread of malaria, at first sight almost a whimsical one,—no less than screening the patient. The mosquito, of course, criminal as she is, does not hatch the parasitesde novoin her own body, but simply sucks them up in a meal of blood from some previous victim. Hence by careful screening of every known case of malaria, mosquitoes are prevented from becoming infected and transmitting the disease. Instead of the screens protecting the victims from the mosquitoes, they protect the mosquitoes against the victim.
This explains why hunters, trappers, and Indians may range a region for years, without once suffering from malaria, while as soon as settlers begin to come in in considerable numbers, it becomes highly malarious. It had to be infected by the coming of a case of the disease.
The notorious prevalence of malaria on the frontier is due to the introduction of the plasmodium into a region swarming with mosquitoes, where there are few window-screens or two-story houses.
No known race has any real immunity against malaria. The negro and other colored races, it is true, are far less susceptible; but this we now know applies only to adults, as the studies of Koch in Africa showed that a large percentage of negro children had the plasmodium in their blood. No small percentage of them die of malaria, but those who recover acquire a certain degree of immunity. Possibly they may be able to acquire this immunity more easily and with less fatality than the white race, but this is the extent of their superiority in this regard. The negro races probably represent the survivors of primitive men, who were too unenterprising to get away from the tropics, and have had to adjust themselves as best they might.
The serious injury wrought in the body by malaria is a household word, and a matter of painfully familiar experience. Scarcely an organ in the body escapes damage, though this may not be discovered till long after the "fever-and-ague" has been recovered from.
As the parasite breeds in the red cells of the blood, naturally its first effect is to destroy huge numbers of these, producing the typical malarialanæmia, or bloodlessness. Instead of 5,000,000 to the cubic centimetre of blood the red cells may be reduced to 2,000,000 or even 1,500,000. The breaking down of these red cells throws their pigment or coloring-matter afloat in the blood; and soaking through all the tissues of the body, this turns a greenish-yellow and gives the well-known sallow skin and yellowish whites of the eyes of swamp-dwellers and "river-rats."
The broken-down scraps of the red blood-cells,together with the toxins of the parasite, are carried to the liver and spleen to be burned up or purified in such quantities that both become congested and diseased, causing the familiar "biliousness," so characteristic of malaria.
The spleen often becomes so enormously enlarged that it can be readily felt with the hand in the left side below the ribs, so that it is not only relied upon as a sign of malaria in doubtful cases, but has even received the popular name of the "ague-cake" in malarious districts.
So full is the blood of the parasites, that they may actually choke up the tiny blood-vessels and capillaries in various organs, so as to block the circulation and cause serious and even fatal congestions. Obstructions of this sort may occur in the brain, the liver, the coats of the stomach, or intestines, and the kidneys; and they are the chief cause of the deadly "congestive chills," or pernicious malarial paroxysms, which we have alluded to.
The kidneys are particularly liable to be attacked in this way; indeed, one of their involvements is so serious and fatal in the tropics as to have been given a separate name, "Blackwater fever," from the quantities of broken-down blood which appear in and blacken the urine.
The vast majority of attacks of malaria are completely recovered from, like any other infection, but it can easily be seen what an injurious effect upon the system may be produced by successive attacks, keeping the entire body saturated with the poison;while there is serious risk of the parasite sooner or later finding some weak spot in the body,—kidney, liver, nervous system,—where its incessant battering works permanent damage.
How long the infection may lurk in the body is uncertain; certainly for months, and possibly for years. Many cases are on record which had typical chills and fever, with abundance of plasmodia in the blood, years after leaving the tropics or other malarious districts; but there is often the possibility of a recent re-infection.
Altogether, malaria is a remarkably bad citizen in any community, and its stamping-out is well worth all it costs.