“Capillary resistance test,”212,257
Carbohydrates,34,59
“Cardiorespiratory syndrome,”200
Cardiovascular system,199
Carrots, antiscorbutic value of,159,160
Central nervous system, gross pathology,93microscopic pathology,104
Cereals, antiscorbutic value of,170germinated,167
Cerebrospinal fluid,203
Chlorides,242–247
Citric acid theory,23
Climate,55
Complement, effect of scurvy on,69
Complexion, characteristic change in,176,184
Complications of scurvy,182,202,205,217
Constipation,27,118–122,207
Cord, spinal, pathology,93,104
Creatinine,244
Cure,236
D
Death, causes of,179,227
Deficiency diseases, general discussion,63, 248
Diagnosis,176,219
Diastase, blood content of,244
Diet, general,59
Digestive disturbances,78
Diphtheria, antitoxin in blood,68as complication of scurvy,217
Drying, effect on vitamines of,66
Duodenum, pathology,89
Dysentery,59,182
E
Economic status,55
Eczema,195
Edema,178,184,196hunger,256war,256
Eggs, antiscorbutic value of,168
Endocrine organs, gross pathology,92microscopic pathology,104extracts of, as preventive,172theory of vitamine action,72
Epidemics,2,217
Epiphyses, separation of,96,181,198
Etiology,35exciting factors in,60
Excretion of vitamine,77
Expeditions, scurvy in Arctic,10
Experimental scurvy,111pathogenesis,116pathology,122symptoms,135
Exudative diathesis,59,256
Eyeball, proptosis,193
F
Familial tendency,58
Fats, in diet, effect on scurvy,59
Fever,181,216
Fœtus, effect of scorbutic diet on,125
Food, excess of,257
Foods, antiscorbutic,143,149proprietary,49
Fractures,95
Frost-bite,180
Fruit juices,153
Fruits, fresh,144
G
Generative organs, pathology,104
Glands, endocrine,72changes in,73,92,104
Glucose, blood content of,244
Grapes, antiscorbutic value of,158
Growth in scurvy,213
Guinea-pig scurvy,112,114
Guinea-pig pathogenesis,116pathology,122relation to human,115symptoms,135
Gums,177,181,184in infantile scurvy,189pathology of,89,100
H
Hair, changes in,194
Heart,200gross pathology,87microscopic pathology,99
Heat, effect on vitamine of,65
Hemorrhages,180,189as early symptoms,178distribution of,84gastric,208orbital,193subperiosteal,95,191urinary,204
History of scurvy,1
Hog, effect of scorbutic diet on,115
Hypophysis,104
I
Infantile scurvy, history,10in artificially fed,40in breast-fed,35increase during World War,21–22relation to epidemic scurvy of adults,15,37relation to rickets,11,110,252symptomatology,183
Infection, as exciting factor,60,218increased liability to,68effect on prognosis,227
Intestines, gross pathology,90microscopic pathology,100
Intravenous use of orange juice,238
Irregularities in course of deficiency diseases,78
J
Jaundice,208
Joints, lesions of,199
K
Kidneys, gross pathology,91microscopic pathology,102
L
Latent scurvy,179,183,187
Laxatives, failure to cure with,28,207
Lemon juice, antiscorbutic value of,153,234dried,155,232ration in British Navy,9,144
Lentils, value as antiscorbutic,167,231
Lice, theory of transmission of scurvy by,30
Lime juice, antiscorbutic value of,156fallacy in regard to,149use in British Navy,144
Liver, gross pathology,91microscopic pathology,101
Lungs, gross pathology,88microscopic pathology,99
Lymph-nodes, gross pathology,92microscopic pathology,101
M
Malnutrition, general,58
Malt soup,50
Marrow, changes in,107
Meat, fresh,147,168salt,146
“Mehlnaerschaden” of Czerny,256
Metabolism in scurvy,241–247
Milk, alkalized,50amount necessary to prevent scurvy,49,117,150boiled,44,65condensed,48dried,46,66,152effect of industrial methods on,43evaporated,45pasteurized,40,65home vs. commercial,42sterilized,44breast, amount necessary to prevent scurvy,36,39,153as cause of beriberi,39cows, antiscorbutic value of,40,152goats, antiscorbutic value of,153
Mineral metabolism in scurvy,241–247
Monkey, scurvy in,114,127pathology,128
Muscles, pathology,97
N
Nails, changes in,194
Necropsy reports,82
Nephritis,205
Nerves, peripheral, in guinea-pigscurvy,132pathology,105
Nervous system, effect of scurvy on,202
Nutrition, general, in scurvy,58,59,213
Nyctalopia,182
O
Orange juice, antiscorbutic value of,153,234“artificial,”33dried,155effect of alkalization of,154intravenous use of,238subcutaneous use of,155peel, antiscorbutic value of,234
Osteogenesis imperfecta,255
Osteomalacia, differentiation of, from scurvy,255
Osteomyelitis, differentiation of, from scurvy,222
Osteoporosis, differentiation of, from scurvy,255
Osteotabes infantum,109
P
Pains, as early symptom,176
Pancreas, gross pathology,91microscopic pathology,104
Pasteurized milk,40
Pathogenesis of scurvy, theories of,23
Pathology of scurvy in guinea-pig,122in man, gross,83microscopic,96in monkey,128
Peas, antiscorbutic value of,167,231
Pellagra,251
Phenols, excretion of,245
Phosphate metabolism,241–247
Pigeon, effect of scorbutic diet on,114
Pneumonia,202
Posture, characteristic, in guinea-pig,136
Posture, characteristic, infant,183
Potassium deficiency theory,23metabolism,241–247
Potatoes, antiscorbutic value of,6,7,146,161,235
Prevention of scurvy,230
Prognosis,225
Protein in diet, effect on scurvy,59
Psychic element in scurvy,57
Pulse,181,201
Pulses, germinated,167,231
Purpura, differential diagnosis,221
Pyorrhœa, relation to lesion of gums,181
R
Racial immunity,56
Rats, effect of scorbutic diet on,114,115
Recurrent scurvy,228
Respirations,201
Retina, hemorrhages in,105
Rheumatism, confusion with scurvy,176,220
Ribs, beading of,197pathology,94in guinea-pig,129,137
Rickets, relation of, to scurvy,11,110,252
Rosary,94,197
S
Sauerkraut, antiscorbutic value of,145
Season, effect on incidence,54
Sex, effect on incidence,56
Shaking, effect on antiscorbutic factor,68
Ship beriberi,250
Skin, pathology,96
Spleen, gross pathology,91microscopic pathology,102
Sprue,256
Starvation, pathology of,125
Stomach, gross pathology,89microscopic pathology,100
Storage of vitamine in body,74
Streptococcus in blood in scurvy,134
Subacute form of scurvy,184
Subcutaneous use of antiscorbutics,155
Swede, antiscorbutic value of,162,235
Symptomatology, in adult,176in infant,183
Syphilis, congenital, differential diagnosis,222,223
T
Teeth, in guinea-pig scurvy,130,137in human scurvy,177
Temperature, in guinea-pig scurvy,141in human scurvy,181,216
Thymus, pathology of,104use of gland in treatment,172
Thyroid, pathology of,104use of gland in treatment,172
Tomatoes, canned, antiscorbutic value of,166,231,234in U. S. Army ration,231
Toxic theory of pathogenesis of scurvy,25
Treatment of scurvy,230duration of,237non-dietetic,239
U
Ultra-violet rays, effect on antiscorbutics,67
Urea content of blood,244of tissues,245
Urine in scurvy,204–206
V
Vegetable juices, keeping qualities of,161
Vegetables, antiscorbutic value of144,158canned,166dehydrated,163effect of heat on,159fresh,144,158ripeness of, effect on antiscorbutic value,160
Vitamine, antiscorbutic, general discussion of,62action of,68,69as antitoxin,69as catalytic agent,70as nutriment,69blood content of,76effect of heat on,65of ultra-violet ray on,67excretion of,77
Vitamine, experimental evidence for,62fate in body,74,77relation to water-soluble factor,65,67relation to antineuritic vitamine,67resistance to chemical and physical processes,64storage in body of,74theory of scurvy,32
W
Weight, loss of,138,213
“White line” of Fraenkel,128,198
World War, scurvy in,15
X
X-ray in diagnosis of scurvy,128,192,198
Y
Yeast, antiscorbutic value of,171