Brometone, 1,1,1-tribrom-2-methyl-propan-2-ol, CBr3·C(OH) (CH3)·CH3= C4H7OBr3, produced by the reaction of acetone on bromoform.
Actions and Uses.—Brometone is claimed to have the sedative action of the bromides without the disadvantage of producing bromism. In doses of 0·3 gramme (5 grains) four or five times a day, in adults, it is claimed to cause no unpleasant results and to produce no disturbance of the digestive organs, and to have no appreciable effect on the secretions. Its action is prompt and its effect is manifest for several hours. In doses exceeding 1·6 grammes (25 grains) daily it may produce dizziness, vertigo, anorexia, and mental hebetude, all of which symptoms disappear on discontinuance of its use. Therapeutically it has been recommended in mild conditions of excitation and insomnia, in so-called narcotic abstinence, in hysteria, and in nervous affections generally. It relieves some forms of cough and is said to produce amelioration in about 60 per cent. of cases of epilepsy. It has been used to relieve dizziness due to labyrinthine disturbances. Dosage.—The dose is 0·3 gramme (5 grains), to be repeated two or three times during twenty-four hours. Manufactured by Parke, Davis & Co., Detroit, Mich.