Chlorbutanol, 1,1,1-trichlor-2-methyl-propan-2-ol, CCl3·C (OH) (CH3)·CH3= C4H7OCl3, produced by the reaction of acetone on chloroform.
Actions and Uses.—It is said to be absorbed unchanged, but tobe decomposed in the body. It is a local anesthetic with an action weaker than that of cocaine, but sufficient to prevent vomiting from gastric irritation. Its antiseptic action is said to be fifteen times as strong as that of boric acid. It acts on the central nervous system similarly to chloral, and although the claim has been made that hypnotic doses are without effect on the circulation and respiration, independent observers have described a fall of blood pressure and interference with respiration in animals, and consider it fully as dangerous as chloral. In man 100 grains caused severe symptoms, but recovery occurred. It is claimed that no habit is induced, but this may be referable to its restricted employment. It is recommended as a mild local anesthetic, in dentistry, etc., as a preservative for hypodermic solutions, for insomnia, vomiting and for spasmodic conditions. It is also said to be useful as introductory to general anesthesia, lessening excitement and nausea. Dosage.—The dose is from 0·3 to 1·5 gramme (5 to 20 grains) dry or in capsules. Hypodermically as a local anesthetic a saturated aqueous solution may be used.