We give herewith a table showing the absolute and relative mortality due to diphtheria in Paris from 1872 to 1905, out of a population of 2,500,000 inhabitants:—
Absolute.Per 100,000Inhabitants.187211356118731164621874100852187513286818761572791877239311718781995951879178383188020489418812211991882224410018831781791884192886188516557418861512671887158570188817297418891706721890166870189113615618921403581893126652189410094118954351718964441718972981218982591018993391319002941119017362819027092619033991519042601019052047
Let us divide this mortality due to diphtheria into three groups (in Paris per 100,000 inhabitants):—
A. Before the discovery of serotherapy, from 1872 to 1888.B. During the period of experimentation with serotherapy, from 1889 to 1894.C. After the generalisation of serotherapy, from 1895 to 1905.
A. Before the discovery of serotherapy, from 1872 to 1888.
B. During the period of experimentation with serotherapy, from 1889 to 1894.
C. After the generalisation of serotherapy, from 1895 to 1905.
We have then the following averages:—
Absolute.Per 100,000 Inhabitants.Before serotherapy165780Intermediary period140258After serotherapy39815
And should these figures not seem sufficiently eloquent, let us set them forth in another form:—
Absolute Mortality.Before thediscovery ofserotherapy,188817291styear ofserotherapy,188917062nd""189016683rd""189113614th""189214635th""189312666th""18941009
At this moment the practice of serotherapy, thanks to Roux, became general in Paris.
1st year, 1895—435.2nd " 1896—444.
During the next six years there were still hesitations and uncertainties as to the best method to be employed.
The mortality during these six years, 1897-1902—439.
Then the practice was definitely established.
The mortality for the three years, 1903-1905—288.
These figures are so eloquent, so striking, so precise, that it is not possible to misunderstand them. They cannot be ignored; and when once they have been set forth, ignorance is no longer permissible, and it is for that reason we have here given them.
In Berlin and in Vienna, it is the same thing. From 1894 the mortality due to diphtheria has diminished to the extent of 150 per cent.
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Harvey.The Pasteur Institute and Vivisection.(Ind. Med. Gaz., 1895, 49-57.)
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Keen (W. W.).Misstatements of the Anti-vivisectionists Again.(Phil. Med. Jour., 1901, 204-206.)
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In January 1908, a Society with the above name was formed in England, the aims and objects of which are clearly stated in the following letter from Lord Cromer, its President; this letter was published in the English newspapers on 24th April 1908:—
Sir,
A Society has been formed, with the name of the Research Defence Society, to make known the facts as to experiments on animals in this country; the immense importance to the welfare of mankind of such experiments; and the great saving of human life and health directly attributable to them.
The great advance that has been made during the last quarter of a century in our knowledge of the functions of the body, and of the causes of disease, would have been impossible without a combination of experiment and observation.
The use of antiseptics, and the modern treatment ofwounds, is the direct outcome of the experiments of Pasteur and Lister. Pasteur's discovery of the microbial cause of puerperal fever has in itself enormously reduced the deaths of women in child-birth.
The nature of tuberculosis is now known, and its incidence has materially diminished.
We owe the invention of diphtheria antitoxin entirely to experiments on animals.
The causes of plague, cholera, typhoid, Mediterranean fever, and sleeping sickness, have been discovered solely by the experimental method.
Not only have a large number of drugs been placed at our disposal, but accurate knowledge has replaced the empirical use of many of those previously known.
The evidence before the Royal Commission has shown that these experiments are conducted with proper care; the small amount of pain or discomfort inflicted is insignificant compared with the great gain to knowledge and the direct advantage to humanity.
While acknowledging in general the utility of the experimental method, efforts have been made by a section of the public to throw discredit on all experiments involving the use of animals. The Research Defence Society will therefore endeavour to make it clear that medical and other scientific men who employ these methods are not less humane than the rest of their countrymen, who daily, though perhaps unconsciously, profit by them.
The Society proposes to give information to all enquirers, to publishprécis, articles, and leaflets, to make arrangements for lectures, to send speakers, if required, to debates, and to assist all who desire to examine the arguments on behalf of experiments on animals. It hopes to establish branches in our chief cities, and thus to be in touch withall parts of the kingdom; and to be at the service of municipal bodies, hospitals, and other public institutions.
The Society was formed on 27th January of the present year, and already numbers more than 800 members.[9]It is not an association of men of science or of medical men alone; its membership has been drawn from all departments of public life, and includes representatives of every class of educated Englishmen and Englishwomen, including many who have taken an active part in the prevention of cruelty to animals. This fact is in itself a remarkable protest against the attacks which have been made on the researches that the Society has been formed to defend.
The annual subscription is five shillings to cover working expenses: but larger subscriptions, or donations, will be gladly received. The acting Hon. Treasurer,pro tem., is Mr J. Luard Pattisson, C.B. (of the Lister Institute),[10]and an account in the Society's name has been opened with Messrs Coutts & Co., 440 Strand. The Hon. Secretary is Mr Stephen Paget, 70 Harley Street, W., to whom all communications should be addressed.
Yours faithfully,Cromer,President.
The following is a list of the pamphlets already issued by the Society:—
1. Letter from the President announcing the formation of the Society, April 24.
2. Report of the inaugural meeting.
3. Experiments on animals during 1907 in Great Britain and Ireland.
4. Some facts as to the administration of the Act.
5. The value of antitoxin in the treatment of diphtheria.
6. Evidence of Sir Frederick Treves.
7. Yellow fever and malaria.
8. Extinction of Malta fever.
9. Have experiments on animals advanced Therapeutics?
10. The work of the Research Defence Society.
11. Vivisection and medicine. Evidence of Lord Justice Fletcher Moulton before the Royal Commission.
All or any of these will be forwarded on application to the Hon. Secretary, Mr Stephen Paget, 70 Harley Street, London, W. Other pamphlets are in active preparation; arrangements are also being made for meetings, and for the organisation of Branch Societies in many parts of the kingdom; the Society is also concerned in the institution of a similar movement for the defence of research in America.
Space does not permit the publication of the full list of members of the Society. The following list of the President and Vice-Presidents, however, will show that those who have joined are representative not only of the leading men and women in the medical profession, but also of those who are pre-eminent in various other branches of science, in literature, politics, art, and theology.
THE EARL OF CROMER, G.C.B., G.C.M.G., O.M.
His Grace the Duke of Abercorn, K.G.
Sir William Abney, K.C.B., F.R.S.
Sir T. Clifford Allbutt, K.C.B., F.R.S.(Regius Professor of Physic, University of Cambridge).
Sir L. Alma-Tadema, O.M., R.A.
Mrs Garrett Anderson, M.D.
Sir William Anson, Bt., D.C.L., M.P.
The Rt. Hon. Lord Avebury, F.R.S.
[A]Sir John Banks, K.C.B., M.D.
The Rt. Hon. Lord Barrymore.
The Marquis of Bath.
Lady Bliss.
Lady Buckley.
Lady Burdon-Sanderson.
Lord Blyth.
The Very Rev. the Dean of Canterbury, D.D.
Earl Cathcart.
Lord Robert Cecil, K.C., M.P.
The Rt. Rev. the Lord Bishop of Chester, D.D.
The Very Rev. the Dean of Chester, D.D.
Lord Cheylesmore, C.V.O.(Chairman, Middlesex Hospital).
The Very Rev. the Dean of Christ Church, D.D.
Sir James Crichton-Browne, F.R.S.
The Countess of Cromer.
The Rt. Hon. Sir Savile Crossley, Bt., M.V.O.
Sir Edmund Hay Currie.
Lord Curzon of Kedleston, G.C.S.I., G.C.I.E., F.R.S.
The Rev. Dr Dallinger, F.R.S.
Francis Darwin, Esq., F.R.S.
Sir George H. Darwin, K.C.B., F.R.S.
Sir James Dewar, F.R.S.
Sir A. Conan Doyle, LL.D.
The Rev. Canon Duckworth, C.V.O.
The Rt. Rev. the Bishop of Edinburgh, D.D.
Earl Egerton.
The Rt. Rev. the Lord Bishop of Exeter, D.D.
Lord Faber.
The Rev. A. M. Fairbairn, D.D., LL.D.(Principal of Mansfield College, Oxford).
Lord Farrer.
Sir Luke Fildes, R.A.
Lord Fortescue.
Sir Thomas Fraser, M.D., F.R.S.(Professor of Clinical Medicine, University of Edinburgh).
Sir David Gill, K.C.B., LL.D., F.R.S.
The Earl of Glasgow, G.C.M.G.
The Rt. Rev. the Lord Bishop of Grantham, D.D.
Field-Marshal Lord Grenfell, G.C.B., G.C.M.G.
The Hon. Walter Guinness, M.P.
The Rt. Hon. the Earl of Halsbury, K.B., F.R.S.
Lord Claud Hamilton.
H. A. Harben, Esq.(Chairman, St Mary's Hospital).
J. T. Helby, Esq.(Chairman, Metropolitan Asylums Board).
Sir Samuel Hoare, Bt.
The Hon. Sydney Holland(Chairman, London Hospital).
Sir Joseph Dalton Hooker, G.C.S.I., F.R.S., O.M.
Sir William Huggins, K.C.B., F.R.S., O.M.
J. Hughlings Jackson, M.D., LL.D., F.R.S.
Montague Rhodes James, Litt.D.(Provost of King's College, Cambridge).
Sir Alfred Jones, K.C.M.G.
The Rt. Rev. the Lord Bishop of Kingston.
The Earl of Kilmorey(Chairman, Charing Cross Hospital).
Lord Lamington, G.C.M.G.
Sir E. Ray Lankester, K.C.B., F.R.S.
R. F. C. Leith, M.Sc., (Professor of Pathology, Birmingham).
The Rt. Hon. Lord Lindley, LL.D., D.C.L., F.R.S.
Sir Norman Lockyer, K.C.B., F.R.S.
The Rt. Hon. Walter Long, M.P.
Henry Lucas, Esq.(Chairman, University College Hospital).
Lord Ludlow.
The Hon. G. W. Spencer Lyttelton, C.B.
Frederick Macmillan, Esq.(Chairman, National Hospital for the Paralysed and Epileptic).
The Rt. Hon. Sir Herbert E. Maxwell, Bt., F.R.S.
Lord Methuen, G.C.B., K.C.V.O.
Her Grace the Duchess of Montrose.
Lady Dorothy Nevill.
The Earl of Northbrook(President, Cancer Hospital).
Lord Northcliffe.
William Osler, M.D., F.R.S.(Regius Professor of Medicine, University of Oxford).
The Rt. Rev. the Lord Bishop of Oxford, D.D.
Sir Gilbert Parker, D.C.L., M.P.
Eden Phillpotts, Esq.
Count Plunkett.
Sir Frederick Pollock, Bt., LL.D., D.C.L.
Sir John Dickson Poynder, Bt., M.P.(Chairman, Great Northern Hospital).
Lady Priestley.
The Rt. Rev. the Bishop of North Queensland, D.D.
Sir William Ramsay, K.C.B., F.R.S.
The Rt. Rev. the Lord Bishop of Rangoon.
Sir James Reid, Bt., G.C.V.O.
Lady Russell Reynolds.
The Very Rev. Hon. the Dean of Ripon, D.D.
Briton Riviere, Esq., R.A., D.C.L.
Mrs Roget.
Mrs Romanes.
Sir Henry Roscoe, D.C.L., LL.D., F.R.S.
[A]The Rt. Hon. the Earl of Rosse, K.P., LL.D., F.R.S.(Chancellor of the University of Dublin).
Lord Rothschild, G.C.V.O.
Sir Arthur Rücker, F.R.S.
The Very Rev. the Dean of Salisbury, D.D.
The Rt. Hon. the Marquis of Salisbury.
The Rt. Hon. the Marquis of Sligo.
Isabel Marchioness of Sligo.
The Rt. Hon. Sir Cecil Clementi Smith, G.C.M.G.
Sir Thomas Smith, Bt., K.C.V.O.
The Hon. W. F. D. Smith, M.P.(Chairman, Removal Fund, King's College Hospital).
The Hon. Sir Richard Solomon, K.C.B., K.C.M.G.
Sir Edgar Speyer, Bt.(President, Poplar Hospital).
The Rt. Hon. Lord Stalbridge.
Lord Stanley, K.C.V.O.
Lord Strathcona, G.C.M.G.
Lady Sutton.
Maj.-Gen. Sir Reginald Talbot, K.C.B.
Sir Frederick Treves, Bt., G.C.V.O.
Sir John Batty Tuke, M.P.
Sir William Turner, K.C.B., F.R.S.(Principal of the University of Edinburgh).
James G. Wainwright, Esq.(Chairman, St Thomas's Hospital).
Earl Waldegrave.
The Rt. Rev. Bishop Welldon.
His Grace the Duke of Wellington, K.G.
A. W. West, Esq.(Treasurer and Chairman, St George's Hospital).
Sir James Whitehead, Bt.(First President of the Lister Institute).
Mrs Robert Peel Wethered.
Sir Samuel Wilks, Bt., F.R.S.
The Rt. Hon. Sir Alfred Wills.
The Rt. Rev. the Lord Bishop of Winchester.
The Rev. H. G. Woods, D.D.(Master of the Temple).
[Note A: Since deceased.]
FOOTNOTES:[9]22nd October 1908. The number of members is now over 1530, of whom 160 are ladies.[10]27th May. Dr Sandwith, 31 Cavendish Square, London, W., is now Hon. Treasurer.
[9]22nd October 1908. The number of members is now over 1530, of whom 160 are ladies.
[9]22nd October 1908. The number of members is now over 1530, of whom 160 are ladies.
[10]27th May. Dr Sandwith, 31 Cavendish Square, London, W., is now Hon. Treasurer.
[10]27th May. Dr Sandwith, 31 Cavendish Square, London, W., is now Hon. Treasurer.